Erythema nodosum, a painful disorder of the subcutaneous fat, is the most common type of panniculitis. Generally, it is idiopathic, although the. Erythema nodosum (EN) is a delayed-type hypersensitivity reaction that most often presents as erythematous, tender nodules on the shins. Erythema nodosum migrans (subacute nodular migratory panniculitis, migratory panniculitis): asymmetrical, unilateral and distributed solely on.
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The condition is one of the most common forms of a rare inflammatory problem called panniculitis that affects subcutaneous fat under the skin. A majority of erythema nodosum EN cases occur in people between the ages of 20 and 45 years old. Women are five times more likely than men to develop EN. The condition is usually relatively harmless, but it can be a sign of an underlying infection, other inflammatory conditions, or an abnormal response to an allergen or medication.
Up to 55 percent of EN cases are idiopathic, meaning they have no known cause. In some cases, EN is the result of an abnormal immune response, most often triggered by infection, medications, or conditions that cause chronic inflammation.
Researchers are not entirely sure how EN develops. One theory is that it may be caused by the buildup of immune complexes in tiny blood vessels and connections in the subcutaneous fat. These buildups lead to inflammation. EN can develop suddenly without any warning signs.
Some people experience non-specific symptoms before EN lesions develop. Many of the early signs of EN, especially joint pain, continue once the sores develop and may last for weeks to months after they have gone.
The symptoms vary between individuals, but once EN lesions have developed, they normally eritemx a few common characteristics. Rarely, the spots may bond together noddosum form a crescent-shaped ring that spreads for a few days before fading.
With proper rest, most cases of EN resolve on their own within 1 to 2 months, with new sores continuing to develop or spread throughout the first few weeks. However, some people experience EN symptoms for 6 months or more. This is more likely if it is caused by an underlying medical condition or untreated infection.
Chronic or long-term EN will also cause joint pain. The treatment recommended for each case of EN depends on nldosum cause. Underlying infections or medical conditions will also require treatment. Hormonal changes are also known to cause EN. About 2 to 5 percent of cases are linked to pregnancy.
EN that develops during pregnancy usually clears after childbirth but may return if the woman becomes pregnant again. Some people who take oral contraceptives, or hormone control medications develop EN, usually within the first few nodksum on the medication.
Despite its uncomfortable symptoms, EN is usually harmless. Sometimes it can be a sign of infection or medical condition that requires treatment, so should always be seen by a doctor. Cases of EN usually resolve with proper rest and basic care within a few months.
But for some people, EN can become chronic and cause joint nkdosum and sores for 6 months to 2 years. If signs or symptoms of EN occur, a person should seek medical attention to rule out the risk of more serious underlying conditions. People should also talk with a doctor if their EN does not bodosum up with rest and home care. Article last reviewed by Mon 5 February Visit our Dermatology category page for the latest news on this subject, or sign up to our newsletter to receive the latest updates on Dermatology.
All references are available in the References tab. Erythema nodosum—a review of an uncommon panniculitis. Clinico-pathological features of erythema nodosum leprosum: A sign nodosuj systemic disease.
Erythema nodosum – review of the literature
American Family Physician75 5— A systemic review on the epidemiological data of erythema nodosum leprosum, a type 2 leprosy reaction. PloS Neglected Tropical Diseases, 7 10e Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients.
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Register take the tour. Erythema nodosum may be caused by an infection or medication.
Erythema nodosum – review of the literature
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