The new technique of hot-melt extrusion/spheronization can produce spherical As used herein, the term “direct compression excipient” is intended to mean a. A continuous-type spheronizer for use in a continuous melt-spheronization . at a predetermined rate directly into an extruder 30, having one or more heating. Direct. Compression. Formulation/Processing Considerations . Extrusion spheronization using water is possible and recommended versus a solution of electrolytes. Carbopol®. P NF. Noveon® AA Polycarbophil. Hot Melt. Extrusion.
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Powdered cellulose as excipient for extrusion-spheronization pellets of a cohesive hydrophobic drug.
Use of cellulose ether containing excipients with microcrystalline cellulose for the production of pellets containing metformin hydrochloride by the process of extrusion-spheronization. Journal of Microencapsulation 14 2: European Journal of Pharmaceutical Sciences 17 Formulation shperonization ranitidine pellets by extrusion-spheronization with little or no microcrystalline cellulose. Pharmaceutical Development and Technology 4 4: Drug Development and Industrial Pharmacy: European Journal of Pharmaceutical Sciences 24 1: Effect of microcrystalline cellulose grade and process variables on pellets prepared by extrusion-spheronization.
Drug Development and Industrial Pharmacy 28 4: A comparative study of the utility of two superdisintegrants in microcrystalline cellulose pellets prepared by extrusion-spheronization. European Journal of Pharmaceutics and Biopharmaceutics 61 Spherknization coprecipitate as disintegrant in microcrystalline cellulose-based pellets elaborated by extrusion-spheronization.
Pharmaceutical Development and Technology 18 1: International Journal of Pharmaceutics European Journal of Pharmaceutics and Biopharmaceutics 57 1: Control of drug release by incorporation of sorbitol or mannitol in microcrystalline-cellulose-based pellets prepared by extrusion-spheronization.
Pharmaceutical Development and Technology 15 6: International Journal of Pharmaceutics Kidlington 1: International Journal of Pharmaceutics 1: Development and evaluation of omeprazole pellets fabricated by sieving-spheronization and extrusion – spheronization process.
Pakistan Journal of Pharmaceutical Sciences 27 3: